STUDY OF PALMAR DERMATOGLYPHICS PATTERN CHANGES IN beta-THALASSEMIA MAJOR PATIENTS

Palmar dermatoglyphics pattern in beta-Thalassemia major patients and in normal subjects were studied to find out any statistically significant changes if present. SETTING AND DESIGN Qualitative and quantitative changes in the pattern may be present, as these patterns are genetically determined. BACKGROUND beta-Thalassemia major is a serious and prevalent form of haemoglobin disorder in these regions with autosomal recessive pattern of inheritance. Study of population by applying different tools is an important aspect of prevention. Dermatoglyphics study may be helpful to know the phenotypic trait of the individual. METHODS AND MATERIALS 50 diagnosed cases of beta-thalassemia major and the equal number of matched control group of either sex were included in the investigation. Palmar imprints were taken by traditional paper and ink method. STATISTICAL ANALYSIS Chi square test and t-test were used. RESULTS AND CONCLUSION Arch, loop and whorl's character, a-b ridge counts and 'atd' angles were studied. Significant rise in number of whorls and changes in 'atd' angles were detected in the cases. This information may be useful in population genetics study, though more detail research is needed.