SYNTHESIS OF 3'-AMINO AND 5'-AMINO HYDANTOIN 2'-DEOXYNUCLEOSIDES

被引：18

作者：

ELBARBARY, AA

KHODAIR, AI

PEDERSEN, EB

NIELSEN, C

机构：

[1] ODENSE UNIV,DEPT CHEM,DK-5230 ODENSE M,DENMARK

[2] STATENS SERUM INST,DEPT VIROL,RETROVIRUS LAB,DK-2300 COPENHAGEN,DENMARK

来源：

NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 1-3期

关键词：

D O I：

10.1080/15257779408013274

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3'-Amino and 5'-amino derivatives of hydantoin 2'-deoxynucleosides have been prepared from the corresponding 3'-phthalimido and 5'-azido nucleosides, respectively, which in turn were prepared by condensation of appropriate sugars with 5-benzylidenehydantoin. The amino nucleosides were tested for their potential activity against HIV and HSV.

引用

页码：707 / 717

页数：11

共 11 条

[1]

CHENG YC, 1974, BIOCHEMISTRY-US, V13, P1179, DOI 10.1021/bi00703a019

[2] MOUSE ASCITES SARCOMA 180 THYMIDYLATE KINASE - GENERAL PROPERTIES, KINETIC ANALYSIS, AND INHIBITION STUDIES [J].