GRADIENT EXPRESSION OF CDX ALONG THE RAT INTESTINE THROUGHOUT POSTNATAL-DEVELOPMENT

被引：42

作者：

FREUND, JN ^{[1
]}

BOUKAMEL, R ^{[1
]}

BENAZZOUZ, A ^{[1
]}

机构：

[1] CNRS,URA 1160,F-59019 LILLE,FRANCE

来源：

FEBS LETTERS | 1992年 / 314卷 / 02期

关键词：

HOMEOGENE; CAUDAL GENE; MESSENGER RNA EXPRESSION; GENE; SEQUENCE; RAT;

D O I：

10.1016/0014-5793(92)80965-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat genomic DNA was isolated by homology with Cdx1, a murine homeogene selectively expressed in intestinal cells of endodermal origin. Southern blot analysis indicated that the rat genome contains a single or a small number of closely related Cdx gene(s). A major 1.7 kb Cdx mRNA was detected in neonate, suckling and adult rats whereas a 6.5 kb mRNA was restricted to sucklings and adults. Both transcripts showed decreasing concentration from the colon towards the proximal part of the small intestine. No obvious correlation could be established with the patterns of expression of transcripts corresponding to markers of cell proliferation and cell differentiation during postnatal development.

引用

页码：163 / 166

页数：4

共 24 条

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