MATERNAL SERUM DOWN-SYNDROME SCREENING - FREE BETA-PROTEIN IS A MORE EFFECTIVE MARKER THAN HUMAN CHORIONIC-GONADOTROPIN

被引：174

作者：

MACRI, JN ^{[1
]}

KASTURI, RV ^{[1
]}

KRANTZ, DA ^{[1
]}

COOK, EJ ^{[1
]}

MOORE, ND ^{[1
]}

YOUNG, JA ^{[1
]}

ROMERO, K ^{[1
]}

LARSEN, JW ^{[1
]}

机构：

[1] GEORGE WASHINGTON UNIV,MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20037

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 163卷 / 04期

关键词：

Down syndrome; free; β-protein; Screening;

D O I：

10.1016/0002-9378(90)90700-H

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The use of quantitative human chorionic gonadotropin measurement in obstetrics has a long and successful history. Prior studies on the utility of human chorionic gonadotropin in Down syndrome screening have utilized assays that measure the intact human chorionic gonadotropin molecule. This study targeted a distinct marker, the human chorionic gonadotropin free β-protein, which is present in second-trimester maternal serum at much lower concentrations than is intact human chorionic gonadotropin. Our study of 29 cases of trisomy 21 and 450 control samples shows 80% detection efficiency with maternal serum α-fetoprotein, the free β-protein, and maternal age in pregnancies under 17 weeks' gestation. We conclude that the combination of maternal serum α-fetoprotein and the human chorionic gonadotropin free β-protein will be useful in the prenatal detection of trisomy 21. © 1990.

引用

页码：1248 / 1253

页数：6

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