INHIBITION OF LIPID-PEROXIDATION BY UBIQUINOL IN SUBMITOCHONDRIAL PARTICLES IN THE ABSENCE OF VITAMIN-E

被引：111
作者：
FORSMARK, P [1 ]
ABERG, F [1 ]
NORLING, B [1 ]
NORDENBRAND, K [1 ]
DALLNER, G [1 ]
ERNSTER, L [1 ]
机构：
[1] KAROLINSKA INST,HUDDINGE HOSP,CLIN RES CTR,S-14186 HUDDINGE,SWEDEN
来源：
FEBS LETTERS | 1991年 / 285卷 / 01期
关键词：
UBIQUINONE; COENZYME-Q; VITAMIN-E; LIPID PEROXIDATION; SUBMITOCHONDRIAL PARTICLE;
D O I：
10.1016/0014-5793(91)80720-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relationship between the antioxidant effects of reduced coenzyme Q10 (ubiquinol, UQH2) and vitamin E (alpha-tocopherol) was investigated in beef heart submitochondrial particles in which lipid peroxidation was initiated by incubation with ascorbate + ADP-Fe3+. These effects were examined after extraction of coenzyme Q10 (UQ-10) and vitamin E from the particles and reincorporation of the same components alone or in combination. The results show that UQH2 efficiently inhibits lipid peroxidation even when vitamin E is absent. It is concluded that UQH2 can inhibit lipid peroxidation directly, without the mediation of vitamin E.
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页码：39 / 43
页数：5
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