INHIBITION OF LIPID-PEROXIDATION BY UBIQUINOL IN SUBMITOCHONDRIAL PARTICLES IN THE ABSENCE OF VITAMIN-E

被引：111

作者：

FORSMARK, P ^{[1
]}

ABERG, F ^{[1
]}

NORLING, B ^{[1
]}

NORDENBRAND, K ^{[1
]}

DALLNER, G ^{[1
]}

ERNSTER, L ^{[1
]}

机构：

[1] KAROLINSKA INST,HUDDINGE HOSP,CLIN RES CTR,S-14186 HUDDINGE,SWEDEN

来源：

FEBS LETTERS | 1991年 / 285卷 / 01期

关键词：

UBIQUINONE; COENZYME-Q; VITAMIN-E; LIPID PEROXIDATION; SUBMITOCHONDRIAL PARTICLE;

D O I：

10.1016/0014-5793(91)80720-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship between the antioxidant effects of reduced coenzyme Q10 (ubiquinol, UQH2) and vitamin E (alpha-tocopherol) was investigated in beef heart submitochondrial particles in which lipid peroxidation was initiated by incubation with ascorbate + ADP-Fe3+. These effects were examined after extraction of coenzyme Q10 (UQ-10) and vitamin E from the particles and reincorporation of the same components alone or in combination. The results show that UQH2 efficiently inhibits lipid peroxidation even when vitamin E is absent. It is concluded that UQH2 can inhibit lipid peroxidation directly, without the mediation of vitamin E.

引用

页码：39 / 43

页数：5

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