ALTERATION OF RETINOL-BINDING-PROTEIN CONCENTRATIONS BY THE SYNTHETIC RETINOID FENRETINIDE IN HEALTHY-HUMAN SUBJECTS

被引:24
作者
DIMITROV, NV
MEYER, CJ
PERLOFF, M
RUPPENTHAL, MM
PHILLIPICH, MJ
GILLILAND, D
MALONE, W
MINN, FL
机构
[1] MICHIGAN STATE UNIV,DEPT STAT & PROBABIL,E LANSING,MI 48824
[2] NCI,DIV CANC PREVENT & CONTROL,CHEMOPREVENT BRANCH,BETHESDA,MD 20205
[3] MCNEIL PHARMACEUT INC,SPRING HOUSE,PA 19477
关键词
fenretinide; kinetics; retinol; retinol-binding protein;
D O I
10.1093/ajcn/51.6.1082
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Normal subjects received fenretinide (HPR), 200 mg/d, on three schedules. Schedule 1 was treatment for 28 d. Schedule 2 consisted of 14 d of treatment, 3 d hiatus, and a second drug course of 14 d, 10,000 IU vitamin A was administered during the 3-d hiatus. Schedule 3 was 14 d of treatment followed by a rest period of 7 d and then 14 d of treatment. Increase in plasma HPR was accompanied by an even higher increase in the metabolite N-(4-methoxyphenyl)-all-trans-retinamide (MPR). The administration of HPR was associated with a significant reduction in retinol-binding protein (RBP), which returned to pretreatment values after the drug treatment was discontinued. Reduction of plasma retinol was also observed. Use of interrupted schedules with resting periods of 3 and 7 d changed HPR, MPR, and RBP concentrations in plasma. Addition of vitamin A did not affect the pattern of the measured variables in the plasma.
引用
收藏
页码:1082 / 1087
页数:6
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