Transcriptional priming of cytoplasmic post-transcriptional regulation

被引：4
作者：
Tirosh, Itay [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, Rehovot, Israel
来源：
TRANSCRIPTION-AUSTIN | 2011年 / 2卷 / 06期
关键词：
post-transcriptional regulation; coupling; transcription; mRNA degradation; nuclear-cytoplasmic shuttling;
D O I：
10.4161/trns.2.6.18608
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent evidence suggests that post-transcriptional events that are executed in the cytoplasm can be pre-determined during transcription. Here I speculate that this is a widespread mode of regulation and discuss the potential mechanisms, advantages and implications of such a regulatory strategy.
引用
收藏
页码：258 / 262
页数：5
相关论文
共 28 条
[1]   Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization [J].
Casolari, JM ;
Brown, CR ;
Komili, S ;
West, J ;
Hieronymus, H ;
Silver, PA .
CELL, 2004, 117 (04) :427-439
[2]  
Choder Mordechai, 2011, Cell Logist, V1, P37, DOI 10.4161/cl.1.1.14465
[3]   Non-coding RNAs: Meet thy masters [J].
Costa, Fabricio F. .
BIOESSAYS, 2010, 32 (07) :599-608
[4]   Mechanisms and Consequences of Alternative Polyadenylation [J].
Di Giammartino, Dafne Campigli ;
Nishida, Kensei ;
Manley, James L. .
MOLECULAR CELL, 2011, 43 (06) :853-866
[5]   Coupled Evolution of Transcription and mRNA Degradation [J].
Dori-Bachash, Mally ;
Shema, Efrat ;
Tirosh, Itay .
PLOS BIOLOGY, 2011, 9 (07)
[6]   Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution [J].
Drummond, D. Allan ;
Wilke, Claus O. .
CELL, 2008, 134 (02) :341-352
[7]   Cracking the RNA polymerase IICTD code [J].
Egloff, Sylvain ;
Murphy, Shona .
TRENDS IN GENETICS, 2008, 24 (06) :280-288
[8]   Major role for mRNA stability in shaping the kinetics of gene induction [J].
Elkon, Ran ;
Zlotorynski, Eitan ;
Zeller, Karen I. ;
Agami, Reuven .
BMC GENOMICS, 2010, 11
[9]   The nuclear nurture and cytoplasmic nature of localized mRNPs [J].
Giorgi, Corinna ;
Moore, Melissa J. .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2007, 18 (02) :186-193
[10]   Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes [J].
Goler-Baron, Vicky ;
Selitrennik, Michael ;
Barkai, Oren ;
Haimovich, Gal ;
Lotan, Rona ;
Choder, Mordechai .
GENES & DEVELOPMENT, 2008, 22 (15) :2022-2027
123