EFFECTS OF ALUMINUM LACTATE ON MURINE NEUROBLASTOMA-CELLS

被引：0

作者：

ZATTA, PF ^{[1
]}

ZAMBENEDETTI, P ^{[1
]}

MASIERO, S ^{[1
]}

机构：

[1] UNIV PADUA,DIPARTIMENTO BIOL,I-35131 PADUA,ITALY

来源：

NEUROTOXICOLOGY | 1994年 / 15卷 / 04期

关键词：

NEUROBLASTOMA; ALUMINUM; NEURITOGENIC EFFECT; ALZHEIMERS DISEASE; DIALYSIS ENCEPHALOPATHY;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aluminum is the most abundant metal and the third most common element in the earth's crust. It's toxicity has emerged as one of the most serious complications in the treatment of chronic renal failure. Aluminum lactate [Al(lac)(3)], at concentrations less than those affecting cell viability (< 5 mM) decreased the capability oi mouse neuroblastoma cells to incorporate C-14-leucine and H-3-thymidine. This decreased capability to synthesize protein and DNA was accompanied by extension of neurites, increased capacity of the cells to take up silver stain, and decreased reactivity to antibodies against neurofilaments and to lectins that recognize cell surface carbohydrate residues. In conclusion, Allac(3) should be considered as a marked cytostatic as well as a strong neuritogenic agent. (C) 1994 Intox Press, Inc.

引用

页码：789 / 797

页数：9

共 28 条

[1]

Alfrey A.C., 1991, ALUMINUM CHEM BIOL M, P73

[2]

AUDUS KL, 1988, RES COMMUN CHEM PATH, V60, P71

[3]

CHARALAMPOUS FC, 1977, ARCH BIOCHEM BIOPHYS, V81, P103

[4]

CORAIN B, 1991, CHEM SOC DA, P169