DIFLUOROMETHYL ORNITHINE PROTECTS AGAINST THE NEUROTOXIC EFFECTS OF INTRASTRIATALLY ADMINISTERED N-METHYL-D-ASPARTATE INVIVO

被引：33

作者：

PORCELLA, A ^{[1
]}

FAGE, D ^{[1
]}

VOLTZ, C ^{[1
]}

CARTER, C ^{[1
]}

SCATTON, B ^{[1
]}

BARTHOLINI, G ^{[1
]}

机构：

[1] SYNTHELABO LERS,31 AVE PAUL VAILLANT COUTURIER,F-92220 BAGNEUX,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 02期

关键词：

NMDA (N-METHYL-D-ASPARTATE); POLYAMINES; ORNITHINE DECARBOXYLASE; NEUROTOXICITY; STRIATUM (RAT);

D O I：

10.1016/0014-2999(91)90469-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The neurotoxic effects of intrastriatally administered N-methyl-D-aspartate (NMDA) (250 nmol), as measured by reductions in striatal choline acetyl transferase activity and by increased binding of the glial marker [H-3]PK 11195 10 days later, were reduced by coinfusion of the irreversible ornithine decarboxylase inhibitor difluoromethylornithine (250 nmol) in the rat. The data suggest a crucial role for the polyamines in NMDA receptor-mediated neurotoxicity.

引用

页码：267 / 269

页数：3

共 50 条

[41] Effects of ischemia on cerebrovascular responses to N-methyl-D-aspartate in piglets
Busija, DW
Meng, W
Bari, F
McGough, PS
Errico, RA
Tobin, JR
Louis, TM
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 270 (04): : H1225 - H1230
[42] RESPIRATORY EFFECTS OF N-METHYL-D-ASPARTATE ON THE VENTROLATERAL MEDULLARY SURFACE
MITRA, J
PRABHAKAR, NR
OVERHOLT, JL
CHERNIACK, NS
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (05) : 1814 - 1819
[43] EFFECTS OF GLUTAMATE, QUISQUALATE, AND N-METHYL-D-ASPARTATE IN NEONATAL BRAIN
YOUNG, RSK
PETROFF, OAC
AQUILA, WJ
YATES, J
EXPERIMENTAL NEUROLOGY, 1991, 111 (03) : 362 - 368
[44] N-METHYL-D-ASPARTATE RECEPTOR PLASTICITY IN KINDLING - QUANTITATIVE AND QUALITATIVE ALTERATIONS IN THE N-METHYL-D-ASPARTATE RECEPTOR CHANNEL COMPLEX
YEH, GC
BONHAUS, DW
NADLER, JV
MCNAMARA, JO
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) : 8157 - 8160
[45] The N-methyl-D-aspartate Receptor, a Precursor to N-methyl-D-aspartate Receptor Encephalitis, is Found in the Squamous Tissue of Ovarian Teratomas
Clark, Rachel M.
Lynch, Maureen P.
Kolp, Rebecca
Zukerberg, Lawrence R.
Growdon, Whitfield B.
Rueda, Bo R.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2014, 33 (06) : 598 - 606
[46] Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors
Mehta, A. K.
Halder, S.
Khanna, N.
Tandon, O. P.
Sharma, K. K.
HUMAN & EXPERIMENTAL TOXICOLOGY, 2012, 31 (01) : 51 - 56
[47] INVIVO PROTECTION OF STRIATUM FROM MPP+ NEUROTOXICITY BY N-METHYL-D-ASPARTATE ANTAGONISTS
SANTIAGO, M
VENERO, JL
MACHADO, A
CANO, J
BRAIN RESEARCH, 1992, 586 (02) : 203 - 207
[48] INVIVO AND INVITRO EVALUATION OF MULTIPLE CONVULSANT DOSES OF N-METHYL-D-ASPARTATE (NMDA) IN MICE
KAPETANOVIC, IM
YONEKAWA, WD
TORCHIN, CD
KUPFERBERG, HJ
FASEB JOURNAL, 1988, 2 (05): : A1069 - A1069
[49] OUABAIN RELEASES STRIATAL POLYAMINES INVIVO INDEPENDENTLY OF N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION
FAGE, D
VOLTZ, C
CARTER, C
JOURNAL OF NEUROCHEMISTRY, 1993, 61 (01) : 261 - 265
[50] N-METHYL-D-ASPARTATE INDUCES REGULAR FIRING PATTERNS IN THE CAT LATERAL HABENULA INVIVO
MEIER, CL
HERRLING, PL
NEUROSCIENCE, 1993, 52 (04) : 951 - 959

← 1 2 3 4 5 →