DIFLUOROMETHYL ORNITHINE PROTECTS AGAINST THE NEUROTOXIC EFFECTS OF INTRASTRIATALLY ADMINISTERED N-METHYL-D-ASPARTATE INVIVO

被引：33
|
作者：
PORCELLA, A [1 ]
FAGE, D [1 ]
VOLTZ, C [1 ]
CARTER, C [1 ]
SCATTON, B [1 ]
BARTHOLINI, G [1 ]
机构：
[1] SYNTHELABO LERS,31 AVE PAUL VAILLANT COUTURIER,F-92220 BAGNEUX,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 02期
关键词：
NMDA (N-METHYL-D-ASPARTATE); POLYAMINES; ORNITHINE DECARBOXYLASE; NEUROTOXICITY; STRIATUM (RAT);
D O I：
10.1016/0014-2999(91)90469-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The neurotoxic effects of intrastriatally administered N-methyl-D-aspartate (NMDA) (250 nmol), as measured by reductions in striatal choline acetyl transferase activity and by increased binding of the glial marker [H-3]PK 11195 10 days later, were reduced by coinfusion of the irreversible ornithine decarboxylase inhibitor difluoromethylornithine (250 nmol) in the rat. The data suggest a crucial role for the polyamines in NMDA receptor-mediated neurotoxicity.
引用
收藏
页码：267 / 269
页数：3
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