DIFLUOROMETHYL ORNITHINE PROTECTS AGAINST THE NEUROTOXIC EFFECTS OF INTRASTRIATALLY ADMINISTERED N-METHYL-D-ASPARTATE INVIVO

被引：33

作者：

PORCELLA, A ^{[1
]}

FAGE, D ^{[1
]}

VOLTZ, C ^{[1
]}

CARTER, C ^{[1
]}

SCATTON, B ^{[1
]}

BARTHOLINI, G ^{[1
]}

机构：

[1] SYNTHELABO LERS,31 AVE PAUL VAILLANT COUTURIER,F-92220 BAGNEUX,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 02期

关键词：

NMDA (N-METHYL-D-ASPARTATE); POLYAMINES; ORNITHINE DECARBOXYLASE; NEUROTOXICITY; STRIATUM (RAT);

D O I：

10.1016/0014-2999(91)90469-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The neurotoxic effects of intrastriatally administered N-methyl-D-aspartate (NMDA) (250 nmol), as measured by reductions in striatal choline acetyl transferase activity and by increased binding of the glial marker [H-3]PK 11195 10 days later, were reduced by coinfusion of the irreversible ornithine decarboxylase inhibitor difluoromethylornithine (250 nmol) in the rat. The data suggest a crucial role for the polyamines in NMDA receptor-mediated neurotoxicity.

引用

页码：267 / 269

页数：3

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