EFFECT OF 6-KETOCHOLESTANOL ON FCCP-INDUCED AND DNP-INDUCED UNCOUPLING IN PLANT-MITOCHONDRIA

被引：20

作者：

VIANELLO, A ^{[1
]}

MACRI, F ^{[1
]}

BRAIDOT, E ^{[1
]}

MOKHOVA, EN ^{[1
]}

机构：

[1] MOSCOW MV LOMONOSOV STATE UNIV,AN BELOZERSKY INST PHYS CHEM BIOL,MOSCOW 119899,RUSSIA

来源：

FEBS LETTERS | 1995年 / 365卷 / 01期

关键词：

UNCOUPLER; FCCP; DNP; 6-KETOCHOLESTANOL; STEROID HORMONE; PLANT MITOCHONDRIA;

D O I：

10.1016/0014-5793(95)00431-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effect of 6-ketocholestanol on FCCP-induced and DNP-induced uncoupling in beef liver and pea stem mitochondria mas studied, under experimental conditions at which this steroid abolished the effect of low concentrations of FCCP and other most potent uncouplers in rat mitochondria [Starkov et al, (1994) FEES Lett., 355, 305-308]. It is shown that, in both types of mitochondria, 6-ketocholestanol prevents or reverses the uncoupling induced by low concentrations of FCCP, but not that caused by high concentrations of FCCP or by any concentration of DNP. Progesterone and male sex hormones, showing recoupling capability in animal mitochondria, appear to be ineffective in the plant system, Cholesterol does not recouple in both animal and plant mitochondria. Plant steroids, such as beta-sitosterol and stigmasterol, are also without effect.

引用

页码：7 / 9

页数：3

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