PREPARATION OF CORE-CORONA TYPE MICROGELS OF POLYACRYLAMIDE

被引：11
作者：
KIM, KS
CHO, SH
KIM, YJ
机构：
[1] CHUNGBUK NATL UNIV,DEPT CHEM ENGN,CHONGJU 360763,SOUTH KOREA
[2] HYEJEON JR COLL,DEPT IND & ENGN CHEM,HONG SEONG EUP 350800,SOUTH KOREA
来源：
POLYMER JOURNAL | 1993年 / 25卷 / 08期
关键词：
PRECIPITATION POLYMERIZATION; MACROMONOMER; MICROSPHERE; CORE-CORONA TYPE; MICROGEL; HYDROGEL;
D O I：
10.1295/polymj.25.847
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Precipitation polymerization of acrylamide (AAm) and acryloyl terminated PEG macromonomer (AtPEGM) was carried out in selective solvents such as alcohol. Fine particles of microgels were obtained according to the mole ratio of AtPEGM and AAm. The particle size of microgels decreased with increasing concentration of AtPEGM and increased with that of AAm. It was found that microgels were stabilized by steric stabilization of AtPEGM and have the morphology of core-corona type with the size distribution of submicron.
引用
收藏
页码：847 / 851
页数：5
相关论文
共 14 条
[1]   PREPARATION OF POLY(3-HYDROXYBUTYRATE) MICROSPHERES CONTAINING LASTET OF AN ANTICANCER DRUG AND ITS APPLICATION TO DRUG DELIVERY SYSTEM [J].
ABE, H ;
YAMAMOTO, Y ;
DOI, Y .
KOBUNSHI RONBUNSHU, 1992, 49 (01) :61-67
[2]  
BADE W, 1984, EUR POLYM J, V20, P505
[3]   KINETIC-STUDY OF THE POLYMERIZATION OF ACRYLAMIDE IN INVERSE MICROEMULSION [J].
CANDAU, F ;
LEONG, YS ;
FITCH, RM .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1985, 23 (01) :193-214
[4]   ACRYLIC MICROSPHERES INVIVO .6. ANTI-TUMOR EFFECT OF MICROPARTICLES WITH IMMOBILIZED L-ASPARAGINASE AGAINST 6C3HED LYMPHOMA [J].
EDMAN, P ;
SJOHOLM, I .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (06) :654-658
[5]   SEEDED POLYMERIZATION OF VINYL-ACETATE USING MONODISPERSE POLYVINYL ACETATE) LATEX-PARTICLES [J].
HAYASHI, S ;
KOMATSU, A ;
HIRAI, T .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1989, 27 (01) :157-169
[6]   STUDIES ON SUSPENSION AND EMULSION .87. ADSORPTION OF TRYPSIN ONTO STYRENE-2-HYDROXYETHYL METHACRYLATE COPOLYMER MICROSPHERES AND ITS ENZYMATIC-ACTIVITY [J].
KAMEI, S ;
OKUBO, M ;
MATSUDA, T ;
MATSUMOTO, T .
COLLOID AND POLYMER SCIENCE, 1986, 264 (09) :743-747
[7]   HYDROGEL MICROSPHERES .2. PRECIPITATION COPOLYMERIZATION OF ACRYLAMIDE WITH COMONOMERS TO PREPARE MONODISPERSE HYDROGEL MICROSPHERES [J].
KAWAGUCHI, H ;
YAMADA, Y ;
KATAOKA, S ;
MORITA, Y ;
OHTSUKA, Y .
POLYMER JOURNAL, 1991, 23 (08) :955-962
[8]   HYDROGEL MICROSPHERES .1. PREPARATION OF MONODISPERSE HYDROGEL MICROSPHERES OF SUB-MICRON OR MICRON SIZE [J].
KAWAGUCHI, H ;
KAWAHARA, M ;
YAGUCHI, N ;
HOSHINO, F ;
OHTSUKA, Y .
POLYMER JOURNAL, 1988, 20 (10) :903-909
[9]   CONTROL OF DRUG RELEASE WITH A COMBINATION OF PRODRUG AND POLYMER MATRIX - ANTITUMOR-ACTIVITY AND RELEASE PROFILES OF 2',3'-DIACYL-5-FLUORO-2'-DEOXYURIDINE FROM POLY(3-HYDROXYBUTYRATE) MICROSPHERES [J].
KAWAGUCHI, T ;
TSUGANE, A ;
HIGASHIDE, K ;
ENDOH, H ;
HASEGAWA, T ;
KANNO, H ;
SEKI, T ;
JUNI, K ;
FUKUSHIMA, S ;
NAKANO, M .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1992, 81 (06) :508-512
[10]  
OKUBO M, 1991, KOBUNSHI, V40, P704
12