A PHASE-I STUDY OF REGIONAL 5-FLUOROURACIL AND SYSTEMIC FOLINIC ACID FOR PATIENTS WITH COLORECTAL LIVER METASTASES

被引：8

作者：

ANDERSON, JH ^{[1
]}

KERR, DJ ^{[1
]}

COOKE, TG ^{[1
]}

MCARDLE, CS ^{[1
]}

机构：

[1] GLASGOW UNIV,CRC,DEPT MED ONCOL,GLASGOW G61 1BD,SCOTLAND

来源：

BRITISH JOURNAL OF CANCER | 1992年 / 65卷 / 06期

关键词：

D O I：

10.1038/bjc.1992.191

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A phase I study was undertaken in order to establish the maximum tolerated dose of intra-hepatic arterial 5-fluorouracil (5-FU) when given in combination with systemic folinic acid. Patients with colorectal liver metastases (n = 10) received escalating doses of 5-FU as a 24 h infusion with a fixed dose (400 mg m-2) of intravenous folinic acid once per week. Dose limiting toxicity (WHO grade > 2) was encountered at 2 g m-2 5-FU. Principal adverse effects were diarrhoea, vomiting and oral ulceration. The recommended dose for phase II studies is 1.5 g m-2 week-1 24 h 5-FU regional infusion with 400 mg m-2 week-1 intravenous folinic acid.

引用

页码：913 / 915

页数：3

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