DIFFERENTIAL EXCISION OF CARCINOGENIC HYDROCARBON-DNA ADDUCTS IN MOUSE EMBRYO CELL-CULTURES

被引：24
作者：
DIPPLE, A
HAYES, ME
机构：
[1] Chemical Carcinogenesis Program, Frederick Cancer Research Center, Frederick
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0006-291X(79)91198-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Primary mouse embryo cell cultures efficiently excise DNA damage introduced by the carcinogens 7-bromomethylbenz[a]anthracene and 3-methylcholanthrene but are inefficient in excision of damage introduced by 7,12-dimethylbenz[a]anthracene. Since exposure of the cells to the latter compound does not impair their capacity for excision of adducts introduced by the bromocompound, the 7,12-dimethylbenz[a]anthracene-DNA adducts are apparently intrinsically difficult to excise.
引用
收藏
页码：1225 / 1231
页数：7
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