DIFFERENTIAL EXCISION OF CARCINOGENIC HYDROCARBON-DNA ADDUCTS IN MOUSE EMBRYO CELL-CULTURES

被引：24

作者：

DIPPLE, A

HAYES, ME

机构：

[1] Chemical Carcinogenesis Program, Frederick Cancer Research Center, Frederick

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)91198-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary mouse embryo cell cultures efficiently excise DNA damage introduced by the carcinogens 7-bromomethylbenz[a]anthracene and 3-methylcholanthrene but are inefficient in excision of damage introduced by 7,12-dimethylbenz[a]anthracene. Since exposure of the cells to the latter compound does not impair their capacity for excision of adducts introduced by the bromocompound, the 7,12-dimethylbenz[a]anthracene-DNA adducts are apparently intrinsically difficult to excise.

引用

收藏

页码：1225 / 1231

页数：7

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