PHARMACOKINETICS OF ALMITRINE IN HEALTHY-VOLUNTEERS AND PATIENTS WITH ESSENTIAL-HYPERTENSION

被引：0

作者：

WILKE, A ^{[1
]}

SIEGMUND, W ^{[1
]}

SCHNEIDER, T ^{[1
]}

WIERSBITZKY, M ^{[1
]}

FRANKE, G ^{[1
]}

机构：

[1] UNIV GREIFSWALD,DEPT INTERNAL MED,O-2200 GREIFSWALD,GERMANY

来源：

BIOMEDICA BIOCHIMICA ACTA | 1991年 / 50卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pharmacokinetic studies with the arterial chemoreceptor stimulant almitrine (100 mg per os) were performed in 12 healthy volunteers and 8 patients with essential hypertension stage I in order to evaluate the suitability of the drug for physiological tests. The parent compound was determined gas-chromatographically. Almitrine was absorbed with maximal serum levels after 1.8 +/- 0.4 h in healthy volunteers and 1.5 +/- 0.3 h in patients. The elimination proceeded biexponentially with terminal half-lives from 14.6 to 43.4 h in volunteers and 12.5 - 45.0 h in patients. Further characteristics were large distribution volumes (16.1 +/- 4.5 ml/g in healthy volunteers, 13.9 +/- 4.7 ml/g in patients) and large interindividual variations of all pharmacokinetic parameters by a factor of 2 to 6. Significant differences between healthy individuals and patients were not observed. The drug was well tolerated. The pharmacokinetic properties of almitrine should be included into its evaluation as a test compound.

引用

页码：183 / 187

页数：5

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