DETERMINATION OF PK VALUES OF GUANOSINE NUCLEOTIDES AND NUCLEOSIDES AND RELATED-COMPOUNDS

被引：0

作者：

LABADI, I ^{[1
]}

LONNBERG, H ^{[1
]}

机构：

[1] TURKU EGYET KEM & BIOKEM INTEZET,TURKU,FINLAND

来源：

MAGYAR KEMIAI FOLYOIRAT | 1990年 / 96卷 / 11-12期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acid-base properties of guanosine-, m7-guanosine monophosphates, and of the latter's methylesters and of some base-substituted guanosine nucleotids were investigated. Protonation constants of the N1 atom of the guanine base and of the phosphate group were determined. Increase and corresponding decrease in the basicity of the N1 and phosphate group reflected intermolecular electrostatic interaction for the 5' isomers of the m7-guanosin nucleotides. A correlation has been found between the acid-base properties, conformation and the inhibition properties of these compounds in some kind of protein synthesis.

引用

页码：508 / 514

页数：7

共 20 条

[1]

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[2]

CARZYNKIEWICZ E, 1981, J MOL BIOL, V153, P451

[3]

CHRISTIENSEN JJ, 1970, BIOCHEMISTRY-US, V9, P7

[4] INHIBITION OF EUKARYOTIC TRANSLATION BY ANALOGS OF MESSENGER-RNA 5'-CAP - CHEMICAL AND BIOLOGICAL CONSEQUENCES OF 5'-PHOSPHATE MODIFICATIONS OF 7-METHYLGUANOSINE 5'-MONOPHOSPHATE [J].