INVITRO ASSESSMENTS OF TRANSDERMAL DEVICES CONTAINING NITROGLYCERIN

被引：22

作者：

HADGRAFT, J ^{[1
]}

LEWIS, D ^{[1
]}

BEUTNER, D ^{[1
]}

WOLFF, HM ^{[1
]}

机构：

[1] SCHWARZ PHARMA AG,W-4019 MONHEIM,GERMANY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 73卷 / 02期

关键词：

TRANSDERMAL DRUG DELIVERY; NITROGLYCERIN; INVITRO RELEASE RATE; SKIN ABSORPTION; SKIN DAMAGE EFFECT;

D O I：

10.1016/0378-5173(91)90035-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The in vitro rates of release of nitroglycerin from a number of products have been determined. The rates were measured in the absence of any skin, with dermatomed skin and skin that had been damaged by successive tape stripping. The results demonstrate the need for care in the interpretation of the data. If conventional Franz-type diffusion cells are used to monitor the rates of release where there is no rate-controlling membrane, it is possible to obtain erroneous results. This is caused by diffusion of additional drug from the polymer that is sandwiched between the ground glass edges of the cell. Considerable 'edge effects' are possible.

引用

页码：125 / 130

页数：6