PLATELET-ACTIVATING-FACTOR ACETYLHYDROLASE ACTIVITY IN THE URINE OF PATIENTS WITH RENAL-DISEASE

被引：11

作者：

KIRSCHBAUM, B

机构：

[1] Division of Nephrology, Department of Medicine, Medical College of Virginia, Richmond

来源：

CLINICA CHIMICA ACTA | 1991年 / 199卷 / 02期

关键词：

PLATELET ACTIVATING FACTOR; PAF; PAF ACETYLHYDROLASE; URINE ENZYMES; RENAL DISEASE;

D O I：

10.1016/0009-8981(91)90105-L

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Platelet activating factor has been demonstrated in blood and urine and has a broad range of effects on kidney function. The kidney possesses the enzymes responsible for PAF synthesis as well as the specific acetylhydrolase which deactivates PAF. We used a radioactive assay to measure PAF-acetylhydrolase activity in urine samples obtained from normal individuals and patients with various nephropathies. Activity was detected in the majority of normal urines with a mean + 2 SD = 0.70 nmol/30 min/ml. Activity exceeding this value was measured in the urines of 11 of 14 patients with diabetes mellitus, 14 of 22 with glomerulonephritis, and 5 of 16 with hypertensive renal disease. Further study is necessary to relate urine hydrolase activity to specific functional and structural abnormalities of the kidney.

引用

页码：139 / 146

页数：8

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[3]

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