PREPARATION, PROPERTIES AND COMPLEXATION ABILITY OF POLYOXYETHYLENE-BIS-ANAESTHESINE

被引：8

作者：

MANOLOVA, N

BARANOVSKY, V

RASHKOV, I

MAXIMOVA, V

机构：

[1] BULGARIAN ACAD SCI,INST POLYMERS,BU-1113 SOFIA,BULGARIA

[2] BULGARIAN ACAD SCI,INST MOLEC BIOL,BU-1113 SOFIA,BULGARIA

来源：

EUROPEAN POLYMER JOURNAL | 1993年 / 29卷 / 05期

关键词：

D O I：

10.1016/0014-3057(93)90134-2

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(ethylene glycol) derivatives of anaesthesine have been prepared and characterized. Complex formation between poly(acrylic acid) or poly(methacrylic acid) and anaesthesine derivatives in dilute aqueous solutions has been studied by potentiometric titration and viscometry. The presence of the hydrophobic anaesthesine groups stabilizes the polycomplexes. The stability is increased with the introduction of hydrophobic end-groups. Anaesthesine derivatives have been found to be of lower toxicity than anaesthesine. The local anaesthetic effect of anaesthesine has been prolonged by its attachment to a polyoxyethylene chain.

引用

页码：721 / 726

页数：6

共 10 条

[1]

ANTIPINA AD, 1972, VYSOKOMOL SOEDIN A, V14, P941

[2] NONSPECIFIC INTERACTIONS IN POLYMER-POLYMER REACTIONS .2. COMPLEX-FORMATION BETWEEN POLYMETHACRYLIC ACID AND MONOSUBSTITUTED POLY(ETHYLENE GLYCOLS) [J].