RELATIVE ANDROGENICITY, BLOOD-PRESSURE LEVELS, AND CARDIOVASCULAR RISK-FACTORS IN YOUNG HEALTHY WOMEN

被引：43

作者：

MANTZOROS, CS ^{[1
]}

GEORGIADIS, EI ^{[1
]}

YOUNG, R ^{[1
]}

EVAGELOPOULOU, C ^{[1
]}

KHOURY, S ^{[1
]}

KATSILAMBROS, N ^{[1
]}

SOWERS, JR ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DIV ENDOCRINOL HYPERTENS & METAB,DETROIT,MI 48201

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1995年 / 8卷 / 06期

关键词：

ANDROGENS; BLOOD PRESSURE; CARDIOVASCULAR RISK FACTORS; WOMEN;

D O I：

10.1016/0895-7061(95)00051-P

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

To test the hypothesis that androgens may play a role in the pathogenesis of atherosclerosis and hypertension, we investigated the association of Delta 5 dehydroepiandrosterone sulfate [DHEAS]) and Delta 4 (free testosterone [FT]) androgens with the resting, seated blood pressure (BP) levels and cardiovascular risk factors in 280 young, healthy women 18 to 24 years of age. After application of multiple regression analysis, systolic BP was positively and independently correlated with the ratio of dehydroepiandrosterone sulfate to free testosterone (DHEAS/FT), fasting insulin levels, and the diastolic BP with DHEAS/FT only. The DHEAS/FT ratio proved to be a stronger predictor of the BP levels than either hormone alone. Further, uric acid concentrations and HDL/total cholesterol ratio were independently correlated with both FT and body mass index in these young women. Serum triglycerides were independently correlated with ET and central body fat distribution. These data suggest that serum androgen concentrations are important independent predictors of cardiovascular risk factors and that the ratio of dehydroepiandrosterone sulfate to free testosterone ratio is an independent predictor of blood pressure levels in young women.

引用

页码：606 / 614

页数：9

共 42 条

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