SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE DERIVATIVES OF 2-ARYLAMINONICOTINIC ACID HYDRAZIDE

被引：0

作者：

MIKHALEV, AI ^{[1
]}

FALALEEVA, LB ^{[1
]}

SHRAMM, NI ^{[1
]}

POLUKHINA, LM ^{[1
]}

ZALESOV, VS ^{[1
]}

PERSHIN, GN ^{[1
]}

机构：

[1] S ORDZHONIKIDZE PHARMACEUT CHEM RES INST, MOSCOW, USSR

来源：

KHIMIKO-FARMATSEVTICHESKII ZHURNAL | 1981年 / 15卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The following derivatives were synthesized: 2-(p-anisodino)nicotinic acid hydrazide; derivatives of 2-(p-anisodino)-nicotinic acid hydrazide; 2-(p-anisodino)-nicotinic acid p-tolylsulfanylhydrazide; 2-anilinonicotinic acid thioamide (VIII) and 2-anilinonicotinic acid amidrazone. Anticonvulsant activity was studied in mice and decreased when a hydrazide group was substituted for an alkylamide group; anticonvulsant activity was lost entirely in derivatives at the hydrazide group. Antitubercular activity was studied in vitro with respect to Mycobacterium tuberculosis strain H37Rv. Compound VIII was most active. The search should be continued for biologically active compounds among these derivatives.

引用

页码：36 / 39

页数：4