PIMOZIDE IN THE MAINTENANCE TREATMENT OF APATHETIC AND EMOTIONALLY WITHDRAWN SCHIZOPHRENICS

被引：3

作者：

CHEADLE, AJ ^{[1
]}

FREEMAN, HL ^{[1
]}

机构：

[1] UNIV MANCHESTER, DEPT PSYCHIAT, MANCHESTER M13 9PL, LANCASHIRE, ENGLAND

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 1979年 / 6卷 / 01期

关键词：

Pimozide; Schizophrenia;

D O I：

10.1185/03007997909109396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An open pilot study was carried out to assess the effectiveness of pimozide as the sole maintenance therapy for chronic institutionalized schizophrenics who were withdrawn and apathetic. A total of 13 patients entered the study and, following withdrawal of all other neuroleptics for 1 month, patients then received pimozide in a dosage increased gradually from 8 mg to 20 mg per day. Patients were assessed using the Brief Psychiatric Rating Scale (BPRS) and the St. Wulston's Ward Behaviour Scale. There was a trend towards improvement when patients were assessed by both rating scales. This was only statistically significant between the pre-pimozide measurement and the 4 and 6-month's assessment on the BPRS. Other differences, including a slight reduction in side-effects, were not statistically significant. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：35 / 43

页数：9

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