Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

被引：12
作者：
Gooch, Nathan [1 ]
Burr, Randon Michael [2 ]
Holt, Dolly J. [3 ]
Gale, Bruce [4 ]
Ambati, Balamurali [2 ]
机构：
[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA
[2] Univ Utah, Moran Eye Ctr, Salt Lake City, UT 84132 USA
[3] Univ Utah, Dept Cardiothorac Surg, Salt Lake City, UT 84112 USA
[4] Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA
来源：
JOURNAL OF FUNCTIONAL BIOMATERIALS | 2013年 / 4卷 / 01期
关键词：
CDR; capsular bag; drug delivery; biocompatibility;
D O I：
10.3390/jfb4010014
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II (R), a polycarbonate urethane. The devices have been optimized using Avastin (R) as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1 beta, MIP-l alpha, MCP-1, IL-1 beta, TNF and TGF-beta 1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
引用
收藏
页码：14 / 26
页数：13
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