Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

被引：11

作者：

Gooch, Nathan ^{[1
]}

Burr, Randon Michael ^{[2
]}

Holt, Dolly J. ^{[3
]}

Gale, Bruce ^{[4
]}

Ambati, Balamurali ^{[2
]}

机构：

[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[2] Univ Utah, Moran Eye Ctr, Salt Lake City, UT 84132 USA

[3] Univ Utah, Dept Cardiothorac Surg, Salt Lake City, UT 84112 USA

[4] Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF FUNCTIONAL BIOMATERIALS | 2013年 / 4卷 / 01期

关键词：

CDR; capsular bag; drug delivery; biocompatibility;

D O I：

10.3390/jfb4010014

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II (R), a polycarbonate urethane. The devices have been optimized using Avastin (R) as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1 beta, MIP-l alpha, MCP-1, IL-1 beta, TNF and TGF-beta 1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.

引用

页码：14 / 26

页数：13

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