RECEPTOR AND ANTIBODY EPITOPES IN HUMAN GROWTH-HORMONE IDENTIFIED BY HOMOLOG-SCANNING MUTAGENESIS

被引：313
作者：
CUNNINGHAM, BC
JHURANI, P
NG, P
WELLS, JA
机构：
[1] GENENTECH INC,DEPT BIOMOLEC CHEM,460 POINT SAN BRUNO BLVD,S SAN FRANCISCO,CA 94080
[2] GENENTECH INC,DEPT ORGAN CHEM,S SAN FRANCISCO,CA 94080
来源：
SCIENCE | 1989年 / 243卷 / 4896期
关键词：
D O I：
10.1126/science.2466339
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：1330 / 1336
页数：7
相关论文
共 54 条
[1]   3-DIMENSIONAL STRUCTURE OF A GENETICALLY ENGINEERED VARIANT OF PORCINE GROWTH-HORMONE [J].
ABDELMEGUID, SS ;
SHIEH, HS ;
SMITH, WW ;
DAYRINGER, HE ;
VIOLAND, BN ;
BENTLE, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (18) :6434-6437
[2]   TEMPERATURE-SENSITIVE MUTATIONS OF BACTERIOPHAGE-T4 LYSOZYME OCCUR AT SITES WITH LOW MOBILITY AND LOW SOLVENT ACCESSIBILITY IN THE FOLDED PROTEIN [J].
ALBER, T ;
SUN, DP ;
NYE, JA ;
MUCHMORE, DC ;
MATTHEWS, BW .
BIOCHEMISTRY, 1987, 26 (13) :3754-3758
[3]   3-DIMENSIONAL STRUCTURE OF AN ANTIGEN-ANTIBODY COMPLEX AT 2.8-A RESOLUTION [J].
AMIT, AG ;
MARIUZZA, RA ;
PHILLIPS, SEV ;
POLJAK, RJ .
SCIENCE, 1986, 233 (4765) :747-753
[4]   COMPARATIVE-STUDY OF INVITRO AND INVIVO MODULATION OF LACTOGENIC AND SOMATOTROPIC RECEPTORS BY NATIVE HUMAN GROWTH-HORMONE AND ITS MODIFIED ANALOG PREPARED BY RECOMBINANT DEOXYRIBONUCLEIC-ACID TECHNOLOGY [J].
ASHKENAZI, A ;
VOGEL, T ;
BARASH, I ;
HADARI, D ;
LEVANON, A ;
GORECKI, M ;
GERTLER, A .
ENDOCRINOLOGY, 1987, 121 (01) :414-419
[5]   MONOCLONAL-ANTIBODIES TO GROWTH-HORMONE AND PROLACTIN [J].
ASTON, R ;
IVANYI, J .
PHARMACOLOGY & THERAPEUTICS, 1985, 27 (03) :403-424
[6]  
AUBERT ML, 1986, INT J PEPT PROT RES, V28, P45
[7]   CONTINUOUS AND DISCONTINUOUS PROTEIN ANTIGENIC DETERMINANTS [J].
BARLOW, DJ ;
EDWARDS, MS ;
THORNTON, JM .
NATURE, 1986, 322 (6081) :747-748
[8]   A SPECIFIC GROWTH HORMONE-BINDING PROTEIN IN HUMAN-PLASMA - INITIAL CHARACTERIZATION [J].
BAUMANN, G ;
STOLAR, MW ;
AMBURN, K ;
BARSANO, CP ;
DEVRIES, BC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (01) :134-141
[9]  
BEWLEY TA, 1986, HUMAN GROWTH HORMONE, P429
[10]   CLONING AND EXPRESSION OF THE RAT PROLACTIN RECEPTOR, A MEMBER OF THE GROWTH-HORMONE PROLACTIN RECEPTOR GENE FAMILY [J].
BOUTIN, JM ;
JOLICOEUR, C ;
OKAMURA, H ;
GAGNON, J ;
EDERY, M ;
SHIROTA, M ;
BANVILLE, D ;
DUSANTERFOURT, I ;
DJIANE, J ;
KELLY, PA .
CELL, 1988, 53 (01) :69-77
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