EFFECT OF NITRO-L-ARGININE ON CEREBRAL BLOOD-FLOW AND MONOAMINE METABOLISM DURING ISCHEMIA/REPERFUSION IN THE MONGOLIAN GERBIL

被引：10

作者：

STRASSER, A ^{[1
]}

YASUMA, Y ^{[1
]}

MCCARRON, RM ^{[1
]}

ISHII, H ^{[1
]}

STANIMIROVIC, D ^{[1
]}

SPATZ, M ^{[1
]}

机构：

[1] NINCDS, NEUROCYTOBIOL SECT, STROKE BRANCH, BETHESDA, MD 20892 USA

来源：

BRAIN RESEARCH | 1994年 / 664卷 / 1-2期

关键词：

CEREBRAL ISCHEMIA; L-ARGININE; NITRO-L-ARGININE; CEREBRAL BLOOD FLOW; SYSTEMIC BLOOD PRESSURE; DOPAMINE METABOLISM;

D O I：

10.1016/0006-8993(94)91970-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inhibition of nitric oxide synthase with nitro-L-arginine (i.p., 40 mg/kg body weight) in contrast to L-arginine (300 mg/kg body weight) delayed the initial recovery of cerebral blood flow (CBF) and altered dopamine (DA) metabolism in brain ischemia/ reperfusion of Mongolian gerbils. Similar changes but more severe were observed with pargyline (monoamine oxidase inhibitor). Data suggest nitric oxide involvement in postischemic CBF recovery and modulation of DA metabolism due to nitro-L-arginine-induced CBF reduction.

引用

页码：197 / 201

页数：5

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