ALTERATIONS IN MITOCHONDRIAL BRANCHED-CHAIN AMINO-ACID-METABOLISM IN BRAIN IN ACUTE HYPERAMMONEMIC STATES

被引：0
作者：
ALEXANDER, J
MURTHY, CRK
机构：
[1] UNIV HYDERABAD,SCH LIFE SCI,HYDERABAD 500134,ANDHRA PRADESH,INDIA
[2] UNIV HLTH SCI CHICAGO MED SCH,DEPT PHYSIOL & BIOPHYS,N CHICAGO,IL 60064
来源：
NEUROSCIENCE LETTERS | 1993年 / 149卷 / 02期
关键词：
LEUCINE; ISOLEUCINE; VALINE; HYPERAMMONEMIA; BRAIN; MITOCHONDRION;
D O I：
10.1016/0304-3940(93)90776-H
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Production of (CO2)-C-14 and [C-14]branched-chain keto acids (BCKA) was determined from [U-C-14]branched-chain amino acids along with the activities of branched-chain amino acid transaminase (BCAA-T) and branched-chain keto acid dehydrogenase (BCKA-DH) in mitochondria isolated from the cerebral cortex of normal and hyperammonemic rats. Results indicated that the production of CO2, but not of keto acids, was suppressed while the activities of BCAA-T and BCKA-DH were not adversely affected in the mitochondria of hyperammonemic rats. Suppression in the oxidation of BCAA in hyperammonemic states was found to be due to increased efflux of BCKA from mitochondria.
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页码：221 / 224
页数：4
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