PINEAL HYPERACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS - MUSCARINIC REGULATION OF INDOLE METABOLISM

被引：8

作者：

FINOCCHIARO, LME ^{[1
]}

SCHEUCHER, A ^{[1
]}

ALVAREZ, AL ^{[1
]}

FINKIELMAN, S ^{[1
]}

NAHMOD, VE ^{[1
]}

PIROLA, CJ ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,INST INVEST MED,SUSTANCIAS VASOACT LAB,DONATO ALVAREZ 3150,RA-1427 BUENOS AIRES,ARGENTINA

来源：

CLINICAL SCIENCE | 1990年 / 79卷 / 05期

关键词：

5-hydroxytryptamine; melatonin; muscarinic activity; pineal gland; spontaneously hypertensive rats;

D O I：

10.1042/cs0790437

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1. Choline acetyltransferase activity and [3H]quinuclidinyl benzylate-binding sites were detected in the pineal gland of normotensive Wistar-Kyoto rats and of spontaneously hypertensive rats. 2. In vitro, muscarinic activation by pilocarpine increased the pineal metabolic production of hydroxyindole derivatives up to 5-hydroxytryptamine and produced a less marked stimulation of melatonin biosynthesis. 3. Electrical field stimulation of pineal gland slices caused similar metabolic effects. 4. Muscarinic blockade with atropine inhibited the effects on hydroxyindole metabolism. 5. [3H]Quinuclidinyl benzylate-binding sites, indicative of muscarinic receptors, were more numerous, and basal 5-hydroxytryptamine and melatonin levels were higher, in the pineal gland of spontaneously hypertensive rats compared with Wistar-Kyoto rats. 6. The atropine-sensitive metabolic effects of pilocarpine and electrical field stimulation on the pineal gland were increased in spontaneously hypertensive rats compared with Wistar-Kyoto rats.

引用

页码：437 / 442

页数：6