Improved Bowel Function in Patients with Spina Bifida After Bone Marrow-Derived Mononuclear Cell Transplantation: A Report of 2 Cases

被引：8
作者：
Nguyen Thanh Liem [1 ]
Vu Duy Chinh [2 ]
Nguyen Thi Thinh [3 ]
Ngo Duy Minh [3 ]
Hoang Minh Duc [1 ]
机构：
[1] Vinmec Res Inst Stem Cell & Gene Technol, Stem Cell & Immune Cell Dept, Hanoi, Vietnam
[2] Vinmec Int Hosp, Ctr Excellence Autism & Cerebral Palsy, Hanoi, Vietnam
[3] Vinmec Int Hosp, Pediat Dept, Hanoi, Vietnam
来源：
AMERICAN JOURNAL OF CASE REPORTS | 2018年 / 19卷
关键词：
Adult Stem Cells; Bone Marrow Transplantation; Spina Bifida Occulta;
D O I：
10.12659/AJCR.909801
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: Congenital defects/diseases Background: Bowel dysfunction is observed in 42.2-71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation. Case reports: Two patients - 14 years old and 11 years old - with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively. Conclusions: BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.
引用
收藏
页码：1010 / 1018
页数：9
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