BIOSYNTHESIS OF ESTROGENS IN PREGNANT AND NON-PREGNANT GUINEA-PIGS

被引：8

作者：

KALLOO, H

BHAVNANI, BR

机构：

[1] MCGILL UNIV, DEPT EXPTL MED, MONTREAL H3C 3G1, QUEBEC, CANADA

[2] UNIV TORONTO, ST MICHAELS HOSP, INST MED SCI, DEPT OBSTET & GYNECOL, TORONTO M5B 1W8, TORONTO, CANADA

[3] UNIV TORONTO, ST MICHAELS HOSP, INST MED SCI, DEPT CLIN BIOCHEM, TORONTO M5B 1W8, TORONTO, CANADA

来源：

ENDOCRINOLOGY | 1978年 / 102卷 / 03期

关键词：

D O I：

10.1210/endo-102-3-966

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Guinea pig ovaries obtained from pregnant and non-pregnant animals, incubated in the presence of a NADPH-generating system, converted [3H]- dehydroepiandrosterone and [14C]testosterone to estradiol. Under the same conditions, no radioactive estrogen could be identified in adrenal and placental incubations. The rate of formation of estradiol from dehydroepiandrosterone was linear during the 30-min incubation. The initial rates of formation for estradiol were 415 × 10-13 and 10.4 × 10-13 mol/min/g tissue for the ovaries from pregnant and non-pregnant guinea pigs, respectively. The formation of estrone was shown only in the pregnant animal, and the initial rate of formation was 36.0 × 10-13 mol/min/g tissue. These in vitro studies suggest that the major site of estrogen formation in both pregnant and non-pregnant guinea pigs is the ovary. © 1978 by The Endocrine Society.

引用

页码：966 / 972

页数：7

共 20 条

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