DIASTEREOSELECTIVE SYNTHESIS OF ALPHA-BROMO AMIDES LEADING TO DIASTEREOMERICALLY ENRICHED ALPHA-AMINO, ALPHA-HYDROXY AND ALPHA-THIOCARBOXYLIC ACID-DERIVATIVES

被引：0

作者：

WARD, RS ^{[1
]}

PELTER, A ^{[1
]}

GOUBET, D ^{[1
]}

PRITCHARD, MC ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,RES CTR,CAMBRIDGE CB2 2QB,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

alpha-Bromo amides derived from Oppolzer's camphorsultam can be prepared diastereoselectively starting from racemic alpha-bromo acids, and undergo epimerisation under appropriate conditions leading to an enhanced d.e.. By reacting the individual isomers or the mixture of diastereoisomers with a suitable nucleophile it is possible to obtain alpha-substituted carboxylic acids, including alpha-amino- alpha-hydroxy- and alpha-thiocarboxylic acid derivatives, in diastereomerically enriched form.

引用

页码：469 / 498

页数：30

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