THE TIPS/TINS LECTURE - THE MOLECULAR-BIOLOGY OF MAMMALIAN GLUTAMATE-RECEPTOR CHANNELS

被引：225
作者：
SEEBURG, PH
机构：
[1] Centre of Molecular Biology (ZMBH), Laboratory of Molecular Neuroendocrinology, 69052 Heidelberg, PO Box 10 62 49
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 08期
关键词：
D O I：
10.1016/0165-6147(93)90047-N
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has revealed the existence of 16 channel subunits that can assemble in homomeric or heteromeric configurations in vitro to form receptor channels with disparate functional properties. This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures.
引用
收藏
页码：297 / 303
页数：7
相关论文
共 74 条
[1]  
ASCHER P, 1988, J PHYSIOL-LONDON, V399, P227
[2]   CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT [J].
BETTLER, B ;
BOULTER, J ;
HERMANSBORGMEYER, I ;
OSHEAGREENFIELD, A ;
DENERIS, ES ;
MOLL, C ;
BORGMEYER, U ;
HOLLMANN, M ;
HEINEMANN, S .
NEURON, 1990, 5 (05) :583-595
[3]   CLONING OF A PUTATIVE GLUTAMATE RECEPTOR - A LOW AFFINITY KAINATE-BINDING SUBUNIT [J].
BETTLER, B ;
EGEBJERG, J ;
SHARMA, G ;
PECHT, G ;
HERMANSBORGMEYER, I ;
MOLL, C ;
STEVENS, CF ;
HEINEMANN, S .
NEURON, 1992, 8 (02) :257-265
[4]   MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF GLUTAMATE RECEPTOR SUBUNIT GENES [J].
BOULTER, J ;
HOLLMANN, M ;
OSHEAGREENFIELD, A ;
HARTLEY, M ;
DENERIS, E ;
MARON, C ;
HEINEMANN, S .
SCIENCE, 1990, 249 (4972) :1033-1037
[5]   DIVALENT ION PERMEABILITY OF AMPA RECEPTOR CHANNELS IS DOMINATED BY THE EDITED FORM OF A SINGLE SUBUNIT [J].
BURNASHEV, N ;
MONYER, H ;
SEEBURG, PH ;
SAKMANN, B .
NEURON, 1992, 8 (01) :189-198
[6]   CONTROL BY ASPARAGINE RESIDUES OF CALCIUM PERMEABILITY AND MAGNESIUM BLOCKADE IN THE NMDA RECEPTOR [J].
BURNASHEV, N ;
SCHOEPFER, R ;
MONYER, H ;
RUPPERSBERG, JP ;
GUNTHER, W ;
SEEBURG, PH ;
SAKMANN, B .
SCIENCE, 1992, 257 (5075) :1415-1419
[7]   CALCIUM-PERMEABLE AMPA-KAINATE RECEPTORS IN FUSIFORM CEREBELLAR GLIAL-CELLS [J].
BURNASHEV, N ;
KHODOROVA, A ;
JONAS, P ;
HELM, PJ ;
WISDEN, W ;
MONYER, H ;
SEEBURG, PH ;
SAKMANN, B .
SCIENCE, 1992, 256 (5063) :1566-1570
[8]   GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].
CHOI, DW .
NEURON, 1988, 1 (08) :623-634
[9]  
COLLINGRIDGE GL, 1989, PHARMACOL REV, V41, P143
[10]  
COLLINGRIDGE GL, 1991, TRENDS PHARM SCI PHA, P42
12345678