SYNTHESIS OF CHIRAL ALPHA-ACETYLENIC CYCLIC AMINES FROM ALPHA-AMINO ACIDS - APPLICATIONS TO DIFFERENTIALLY CONSTRAINED OXOTREMORINE ANALOGUES AS MUSCARINIC AGENTS

被引：28

作者：

CHUNG, JYL ^{[1
]}

WASICAK, JT ^{[1
]}

机构：

[1] ABBOTT LABS,DIV NUCL RES,DEPT 47W,PHARMACEUT DISCOVERY,ABBOTT PK,N CHICAGO,IL 60064

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)94471-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of the Corey-Fuchs reaction on Boc-prolinal, Boc-4-hydroxyprolinal, Bocpiperidinal and Boc-serinal derivatives to give chiral 2-pyrrolidinyl-, 2-piperidinyl- and 4-oxazolidinyl-acetylene derivatives provided rapid access to a number of differentially constrained oxotremorine analogues as muscarinic agents. © 1990.

引用

页码：3957 / 3960

页数：4

共 9 条

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