LOCALIZATION OF AN ACETYLCHOLINE-RECEPTOR INTRON TO THE NUCLEAR-MEMBRANE

被引：45
作者：
BERMAN, SA
BURSZTAJN, S
BOWEN, B
GILBERT, W
机构：
[1] BAYLOR UNIV,DEPT NEUROL,HOUSTON,TX 77030
[2] BAYLOR UNIV,DEPT CELL BIOL,HOUSTON,TX 77030
[3] HARVARD UNIV,DEPT CELLULAR & DEV BIOL,CAMBRIDGE,MA 02138
来源：
SCIENCE | 1990年 / 247卷 / 4939期
关键词：
D O I：
10.1126/science.1688472
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The first intron of the RNA for the acetylcholine receptor (AChR) a subunit shows a ringlike distribution around nuclei in multinucleated myotubes by in situ hybridization. This pattern is not observed for an actin intron or Ul RNA. Quantitation of the intron sequences reveals large variations in the amount of both the AChR and actin introns between nuclei within the same myotube, although all nuclei express equivalent amounts of Ul RNA. This differential RNA expression indicates that nuclei can individually control expression of messenger RNAs. The restricted distribution of the AChR intron RNA suggests a previously unknown step in RNA processing.
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页码：212 / 214
页数：3
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