INDOMETHACIN AND RENAL-FUNCTION IN PREMATURE-INFANTS WITH PERSISTENT PATENT DUCTUS-ARTERIOSUS

被引：124

作者：

CIFUENTES, RF

OLLEY, PM

BALFE, JW

RADDE, IC

SOLDIN, SJ

机构：

[1] HOSP SICK CHILDREN, RES INST, TORONTO M5G 1X8, ONTARIO, CANADA

[2] UNIV TORONTO, DEPT PAEDIAT, TORONTO M5S 1A1, ONTARIO, CANADA

来源：

JOURNAL OF PEDIATRICS | 1979年 / 95卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0022-3476(79)80775-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Renal function during indomethacin treatment was studied in 12 premature infants with patent ductusarteriosus. Decreases in urinary flow rate, GFR, and CH by 56, 27, and 66% respectively, occurred during Indo therapy. Urinary excretion rates of ions were also reduced: Na by 70%, Cl by 79%, K by 40%. These changes were accompanied by slight decreases in plasma sodium concentration and osmolality. Except for GFR and urinary Na and osmolality, all these functions retured to pretreatment values one to two weeks after stopping the drug. © 1979 The C. V. Mosby Company.

引用

页码：583 / 587

页数：5

共 28 条

[1] THE DETERMINATION OF MAGNESIUM IN BIOLOGICAL FLUIDS AND TISSUES BY FLAME SPECTROPHOTOMETRY [J].