HLA-B27 SUBTYPES IN THE SPONDARTHROPATHIES

被引:0
作者
MACLEAN, IL
IQBALL, S
WOO, P
KEAT, ACS
HUGHES, RA
KINSLEY, GH
KNIGHT, SC
机构
[1] CLIN RES CTR, DIV IMMUNOL MED, ANTIGEN PRESENTAT RES GRP, HARROW HA1 3UJ, MIDDX, ENGLAND
[2] CLIN RES CTR, DIV MOLEC RHEUMATOL, HARROW HA1 3UJ, MIDDX, ENGLAND
[3] WESTMINSTER MED SCH & HOSP, DEPT RHEUMATOL, LONDON SW1P 2AP, ENGLAND
[4] GUYS HOSP, DEPT MED, LONDON SE1 9RT, ENGLAND
关键词
MAJOR HISTOCOMPATIBILITY COMPLEX; ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; HLA AND DISEASE;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The spondarthropathy (Sp)-associated HLA-B27 antigen includes at least seven subtypes, B*2701-07, of which 01, 02, 05 and 07 occur in Caucasians. This study examined the B27 subtype distribution in British patients with Sp. The 133 HLA-B27+ subjects comprised 94 European Caucasian Sp (58 ankylosing spondylitis (AS), 22 reactive arthritis (ReA; 11 sexually acquired (SARA), 11 enteric (EReA)), eight undifferentiated Sp (USp), and six pauciarticular juvenile-onset chronic arthritis (pJCA)) patients, and 34 healthy Caucasian controls, together with four Asian Indian and one Chinese. S-35-labelled B27 was immunoprecipitated with anti-B27 MoAbs, and subtyped according to isoelectric point (pI) following isoelectric focussing. The use of B27 MoAb permitted subtype assignment without full class I HLA typing. The vast majority (95%) were B*2705 (Caucasian controls 31/34; AS 55/58; ReA 21/22; USp 8/8, and pJCA 6/6; Indian control 1/1 and AS 2/3; Chinese pJCA 1/1), and the remainder B*2702. No B*2701 or 07 subjects were identified. AS occurs in both B*2702 and 05 subjects, and we extend this observation to small numbers of ReA and of Indian AS subjects. This implicates molecular features shared between B27 subtypes, rather than subtype-determining regions of the antigen, in Sp pathogenesis.
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页码:214 / 219
页数:6
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