4-HYDROXYNONENAL IS DEGRADED TO MERCAPTURIC ACID CONJUGATE IN RAT-KIDNEY

被引：25

作者：

PETRAS, T

SIEMS, WG

GRUNE, T

机构：

[1] HUMBOLDT UNIV BERLIN,FAC MED CHARITE,PHYS THERAPY CLIN,D-10098 BERLIN,GERMANY

[2] HERZOG JULIUS HOSP RHEUMATOL & ORTHOPAED,BAD HARZBURG,GERMANY

[3] HUMBOLDT UNIV BERLIN,FAC MED CHARITE,REHABIL CLIN,D-10098 BERLIN,GERMANY

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1995年 / 19卷 / 05期

关键词：

LIPID PEROXIDATION; 4-HYDROXYNONENAL; MERCAPTURIC ACID; ALDEHYDE METABOLISM; KIDNEY; FREE RADICALS;

D O I：

10.1016/0891-5849(95)00060-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytotoxic lipid peroxidation product 4-hydroxynonenal (HNE) was infused into rat kidney. During the first 2 min a rapid degradation of a 100 mu M HNE solution was demonstrated. After 5 min the consumption rate of 4-HNE reached a steady state of about 75 nmoles/ml. The total HNE consumption rate was about 200 nmoles/g w.w./min. The excretion rate into urine was about 0.1% of total HNE consumption. It could be demonstrated that the HNE-mercapturic acid formation takes place in the kidney. The formation of the HNE-mercapturic acid contributes up to 6% to total HNE consumption. Within 10 min of perfusion 2% of the HNE-mercapturic acid were excreted into urine. The residual 98% flow back into the blood circulation.

引用

页码：685 / 688

页数：4

共 16 条

[1] INHIBITION OF GAMMA-GLUTAMYL-TRANSFERASE TRANSPEPTIDASE AND INDUCTION OF GLUTATHIONURIA BY GAMMA-GLUTAMYL-TRANSFERASE AMINO-ACIDS [J].