MANNICH REACTIONS OF CEPHALOSPORIN SULFOXIDES AND SULFONES WITH IMONIUM-SALTS - AN IMPROVED SYNTHESIS OF 2-METHYLENE-CEPHALOSPORINS

被引：4

作者：

GUNDA, TE

机构：

[1] Research Group for Antibiotics, Hungarian Academy of Sciences, H-4010, Debrecen

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 20期

关键词：

D O I：

10.1080/00397919208021124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Methylenecephem-1-oxides (4) or -1,1-dioxides (6) can be very conveniently obtained through the use of dimethyl(methylene)imonium salts, which can be prepared in situ or in advance from bis(N,N-dimethylamino)methane (2) and a reactive acid derivative.

引用

收藏

页码：2979 / 2986

页数：8

相关论文

共 18 条

[1]

BACKVALL JE, 1987, J AM CHEM SOC, V109, P6396

[2] PREPARATION OF 2-EXOMETHYLENE PENAM AND PENICILLIN-2-CARBOXYLATE SYSTEMS [J].

BALDWIN, JE ;

FORREST, AK ;

KO, S ;

SHEPPARD, LN .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (02) :81-83

[3] MANNICH REACTIONS OF ARYLTRIALKYLSTANNANES IN APROTIC-SOLVENTS [J].

COOPER, MS ;

FAIRHURST, RA ;

HEANEY, H ;

PAPAGEORGIOU, G ;

WILKINS, RF .

TETRAHEDRON, 1989, 45 (04) :1155-1166

[4]

DESOLMS SJ, 1976, J ORG CHEM, V41, P2650, DOI 10.1021/jo00877a034

[5] NEW REACTIONS OF DEOXYVASICINONE .3. [J].

DUNN, AD ;

KINNEAR, KI .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (02) :311-312

[6]

GUNDA TE, 1990, LIEBIGS ANN CHEM, P311

[7]

GUNDA TE, 1991, LIEBIGS ANN CHEM, P1349

[8] MANNICH REACTIONS OF NUCLEOPHILIC AROMATIC-COMPOUNDS INVOLVING AMINALS AND ALPHA-AMINO ETHERS ACTIVATED BY CHLOROSILANE DERIVATIVES - CATALYSIS BY CHLOROTRIMETHYLSILANE [J].

HEANEY, H ;

PAPAGEORGIOU, G ;

WILKINS, RF .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (17) :1161-1163

[9] NEW SYNTHESIS OF 8-CHLORO-1-[2-(DIMETHYLAMINO)ETHYL]-6-PHENYL-4H-S-TRIAZOLO[4,3-A][1,4]-BENZODIAZEPINE, WHICH HAS ANTI-DEPRESSANT PROPERTIES [J].

HESTER, JB .

JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (23) :4165-4169

[10] 1-(2-AMINOETHYL)-6-ARYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPINES WITH DIURETIC AND NATRIURETIC ACTIVITY [J].

HESTER, JB ;

LUDENS, JH ;

EMMERT, DE ;

WEST, BE .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (06) :1157-1163