PARATHYROID HYPERTENSIVE FACTOR IS PRESENT IN DOCA-SALT BUT NOT 2-KIDNEY ONE-CLIP HYPERTENSIVE RATS

被引：19

作者：

LEWANCZUK, RZ ^{[1
]}

PANG, PKT ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PHYSIOL,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 10期

关键词：

PARATHYROID HYPERTENSIVE FACTOR; DOCA-SALT; 2-KIDNEY-ONE-CLIP;

D O I：

10.1093/ajh/4.10.802

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In order to determine whether the expression of parathyroid hypertensive factor (PHF) is secondary to hypertension or whether it is specifically related to low-renin hypertension, PHF levels were measured in DOCA-salt and two-kidney-one-clip (2K-1C) hypertensive rats. Despite equivalent elevations of blood pressure, PHF was detected in the DOCA-salt rats, but not in the 2K-1C rats (17.5 +/- 3.1 mm Hg, P < .0001 v 0.9 +/- 2.8 mm Hg, P = NS, respectively). Moreover, PHF levels correlated with mean arterial pressure in the DOCA-salt group (r = 0.91, P < .0001). We conclude that PHF expression is not a secondary phenomenon caused by hypertension, but rather may be causally related to the development of low-renin forms of hypertension.

引用

页码：802 / 805

页数：4