THE STUDY OF PHYSICOCHEMICAL PROPERTIES OF SOLID DISPERSIONS OF IBUPROFEN IN THE PRESENCE OF CHITOSAN

被引：5

作者：

Grimling, Bozena ^{[1
]}

Meler, Jan ^{[1
]}

Szczesniak, Maria ^{[1
]}

Pluta, Janusz ^{[1
]}

Gorniak, Agata ^{[1
]}

机构：

[1] Silesian Piasts Mem Med Univ Wroclaw, Fac Pharm, Ul Borowska 211a, PL-50556 Wroclaw, Poland

来源：

PROGRESS ON CHEMISTRY AND APPLICATION OF CHITIN AND ITS DERIVATIVES | 2015年 / 20卷

关键词：

solid dispersion; dissolution; chitosan; ibuprofen;

D O I：

10.15259/PCACD.20.06

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan M eta = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1: 9. 3: 7 and 5: 5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1: 9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.

引用

页码：64 / 72

页数：9

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