THE NA+-DEPENDENCE OF NA+-ACTIVATED K+-CHANNELS (IK(NA)) IN GUINEA-PIG VENTRICULAR MYOCYTES, IS DIFFERENT IN EXCISED INSIDE OUT PATCHES AND CELL ATTACHED PATCHES

被引：13
|
作者：
RODRIGO, GC
机构：
[1] Department of Physiological Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1993年 / 422卷 / 05期
基金：
英国惠康基金;
关键词：
K-CHANNELS; INTRACELLULAR NA; CADEPLETION; CARDIAC MYOCYTE;
D O I：
10.1007/BF00375082
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Single Na+-activated K+-channels were recorded from intact guinea-pig ventricular myocytes perfused with Ca-free, Mg-free Tyrode, to increase [Na+]i. The activity of these channels increases with the time of perfusion with this solution and decreases when the bathing sodium is reduced. The activity of the Na+-activated K+-channel is greater in the cell attached patches than from excised cell free patches, at the same [Na+]. It is suggested that this K+ channel is significantly active in intact cells within the physiological range of [Na]i.
引用
收藏
页码：530 / 532
页数：3
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