THE SP1 TRANSCRIPTION FACTOR GENE (SP1) AND THE 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR GENE (VDR) ARE COLOCALIZED ON HUMAN-CHROMOSOME ARM 12Q AND RAT CHROMOSOME-7

被引：66
作者：
SZPIRER, J
SZPIRER, C
RIVIERE, M
LEVAN, G
MARYNEN, P
CASSIMAN, JJ
WIESE, R
DELUCA, HF
机构：
[1] GOTHENBURG UNIV,DEPT GENET,S-40033 GOTHENBURG,SWEDEN
[2] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM
[3] UNIV WISCONSIN,COLL AGR & LIFE SCI,DEPT BIOCHEM,MADISON,WI 53706
来源：
GENOMICS | 1991年 / 11卷 / 01期
关键词：
D O I：
10.1016/0888-7543(91)90114-T
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
By means of somatic cell hybrids segregating either human or rat chromosomes, the genes encoding the transcription factor Sp1 (SP1) and the 1,25-dihydroxyvitamin D3 receptor (VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This result implies that the locus for the clinical disorder vitamin D dependency rickets type II maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-γ (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on these chromosomes. © 1991.
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页码：168 / 173
页数：6
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