Breast Cancer Genetic Counseling: A Surgeon's Perspective

被引:12
作者
Agnese, Doreen M. [1 ]
Pollock, Raphael E. [1 ]
机构
[1] Ohio State Univ, Dept Surg, Div Surg Oncol, Columbus, OH 43210 USA
关键词
breast cancer; genetic risk assessment; genetic counseling; genetic testing; hereditary breast cancer;
D O I
10.3389/fsurg.2016.00004
中图分类号
R61 [外科手术学];
学科分类号
摘要
As surgeons who care for patients with breast cancer, the possibility of a cancer diagnosis being related to a hereditary predisposition is always a consideration. Not only are we as surgeons always trying to identify these patients and families but also we are often asked about a potential hereditary component by the patients and their family members. It is therefore critical that we accurately assess patients to determine who may benefit from genetic testing. Importantly, the potential benefit for identifying a hereditary breast cancer extends beyond the patient to other family members and the risk may not be only for the development of breast cancers, but for other cancers as well. This review was written from the perspective of a surgeon with additional training in cancer genetics in an effort to provide a unique perspective on the issue and feel that a review of some of the more practical considerations is important.
引用
收藏
页数:7
相关论文
共 40 条
[11]   Advances in PARP inhibitors for the treatment of breast cancer [J].
Dizdar, Omer ;
Arslan, Cagatay ;
Altundag, Kadri .
EXPERT OPINION ON PHARMACOTHERAPY, 2015, 16 (18) :2751-2758
[12]   Predictors that Influence Contralateral Prophylactic Mastectomy Election Among Women with Ductal Carcinoma In Situ Who Were Evaluated for BRCA Genetic Testing [J].
Elsayegh, Nisreen ;
Kuerer, Henry M. ;
Lin, Heather ;
Barrera, Angelica M. Gutierrez ;
Jackson, Michelle ;
Muse, Kimberly I. ;
Litton, Jennifer K. ;
Albarracin, Constance ;
Afrough, Aimaz ;
Hortobagyi, Gabriel N. ;
Arun, Banu K. .
ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (11) :3466-3472
[13]   Factors determining dissemination of results and uptake of genetic testing in families with known BRCA1/2 mutations [J].
Finlay, Esme ;
Stopfer, Jill E. ;
Burlingame, Eric ;
Evans, Katherine Goldfeder ;
Nathanson, Katherine L. ;
Weber, Barbara L. ;
Armstrong, Katrina ;
Rebbeck, Timothy R. ;
Domchek, Susan M. .
GENETIC TESTING, 2008, 12 (01) :81-91
[14]   Dealing with the unexpected: consumer responses to direct-access BRCA mutation testing [J].
Francke, Uta ;
Dijamco, Cheri ;
Kiefer, Amy K. ;
Eriksson, Nicholas ;
Moiseff, Bianca ;
Tung, Joyce Y. ;
Mountain, Joanna L. .
PEERJ, 2013, 1
[15]   Breast cancer in women at high risk: The role of rapid genetic testing for BRCA1 and-2 mutations and the consequences for treatment strategies [J].
Francken, Anne Brecht ;
Schouten, Philip C. ;
Bleiker, Eveline M. A. ;
Linn, Sabine C. ;
Rutgers, Emiel J. Th. .
BREAST, 2013, 22 (05) :561-568
[16]   LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21 [J].
HALL, JM ;
LEE, MK ;
NEWMAN, B ;
MORROW, JE ;
ANDERSON, LA ;
HUEY, B ;
KING, MC .
SCIENCE, 1990, 250 (4988) :1684-1689
[17]   Cancer genetic risk assessment for individuals at risk of familial breast cancer [J].
Hilgart, Jennifer S. ;
Coles, Bernadette ;
Iredale, Rachel .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (02)
[18]   All in the family:: Evaluation of the process and content of sisters' communication about BRCA1 and BRCA2 genetic test results [J].
Hughes, C ;
Lerman, C ;
Schwartz, M ;
Peshkin, BN ;
Wenzel, L ;
Narod, S ;
Corio, C ;
Tercyak, KP ;
Hanna, D ;
Isaacs, C ;
Main, D .
AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 107 (02) :143-150
[19]  
Julian-Reynier C, 2000, AM J MED GENET, V94, P13, DOI 10.1002/1096-8628(20000904)94:1<13::AID-AJMG4>3.0.CO
[20]  
2-T