Breast Cancer Genetic Counseling: A Surgeon's Perspective

被引:12
作者
Agnese, Doreen M. [1 ]
Pollock, Raphael E. [1 ]
机构
[1] Ohio State Univ, Dept Surg, Div Surg Oncol, Columbus, OH 43210 USA
关键词
breast cancer; genetic risk assessment; genetic counseling; genetic testing; hereditary breast cancer;
D O I
10.3389/fsurg.2016.00004
中图分类号
R61 [外科手术学];
学科分类号
摘要
As surgeons who care for patients with breast cancer, the possibility of a cancer diagnosis being related to a hereditary predisposition is always a consideration. Not only are we as surgeons always trying to identify these patients and families but also we are often asked about a potential hereditary component by the patients and their family members. It is therefore critical that we accurately assess patients to determine who may benefit from genetic testing. Importantly, the potential benefit for identifying a hereditary breast cancer extends beyond the patient to other family members and the risk may not be only for the development of breast cancers, but for other cancers as well. This review was written from the perspective of a surgeon with additional training in cancer genetics in an effort to provide a unique perspective on the issue and feel that a review of some of the more practical considerations is important.
引用
收藏
页数:7
相关论文
共 40 条
[1]   The psychological impact of breast and ovarian cancer preventive options in BRCA1 and BRCA2 mutation carriers [J].
Borreani, C. ;
Manoukian, S. ;
Bianchi, E. ;
Brunelli, C. ;
Peissel, B. ;
Caruso, A. ;
Morasso, G. ;
Pierotti, M. A. .
CLINICAL GENETICS, 2014, 85 (01) :7-15
[2]   Psychological impact of genetic counseling for familial cancer: A systematic review and meta-analysis [J].
Braithwaite, D ;
Emery, J ;
Walter, F ;
Prevost, AT ;
Sutton, S .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (02) :122-133
[3]   Genetic Assessment of Breast Cancer Risk in Primary Care Practice [J].
Burke, Wylie ;
Culver, Julie ;
Pinsky, Linda ;
Hall, Sarah ;
Reynolds, Susan E. ;
Yasui, Yutaka ;
Press, Nancy .
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2009, 149A (03) :349-356
[4]   Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients [J].
Byrski, T. ;
Huzarski, T. ;
Dent, R. ;
Gronwald, J. ;
Zuziak, D. ;
Cybulski, C. ;
Kladny, J. ;
Gorski, B. ;
Lubinski, J. ;
Narod, S. A. .
BREAST CANCER RESEARCH AND TREATMENT, 2009, 115 (02) :359-363
[5]   Pathologic Complete Response Rates in Young Women With BRCA1-Positive Breast Cancers After Neoadjuvant Chemotherapy [J].
Byrski, Tomasz ;
Gronwald, Jacek ;
Huzarski, Tomasz ;
Grzybowska, Ewa ;
Budryk, Magdalena ;
Stawicka, Malgorzata ;
Mierzwa, Tomasz ;
Szwiec, Marek ;
Wisniowski, Rafal ;
Siolek, Monika ;
Dent, Rebecca ;
Lubinski, Jan ;
Narod, Steven .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (03) :375-379
[6]   BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance [J].
Chabalier, C. ;
Lamare, C. ;
Racca, C. ;
Privat, M. ;
Valette, A. ;
Larminat, F. .
CELL CYCLE, 2006, 5 (09) :1001-1007
[7]   Cognitive and Psychological Impact of BRCA Genetic Counseling in Before and After Definitive Surgery Breast Cancer Patients [J].
Christie, Juliette ;
Quinn, Gwendolyn P. ;
Malo, Teri ;
Lee, Ji-Hyun ;
Zhao, Xiuhua ;
McIntyre, Jessica ;
Brzosowicz, Jennifer ;
Jacobsen, Paul B. ;
Vadaparampil, Susan T. .
ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (13) :4003-4011
[8]   Differences in BRCA counseling and testing practices based on ordering provider type [J].
Cragun, Deborah ;
Camperlengo, Lucia ;
Robinson, Emily ;
Caldwell, Meghan ;
Kim, Jongphil ;
Phelan, Catherine ;
Monteiro, Alvaro N. ;
Vadaparampil, Susan T. ;
Sellers, Thomas A. ;
Pal, Tuya .
GENETICS IN MEDICINE, 2015, 17 (01) :51-57
[9]   Variants of uncertain significance in BRCA testing: evaluation of surgical decisions, risk perception, and cancer distress [J].
Culver, J. O. ;
Brinkerhoff, C. D. ;
Clague, J. ;
Yang, K. ;
Singh, K. E. ;
Sand, S. R. ;
Weitzel, J. N. .
CLINICAL GENETICS, 2013, 84 (05) :464-472
[10]   Development of the Informing Relatives Inventory (IRI): Assessing Index Patients' Knowledge, Motivation and Self-Efficacy Regarding the Disclosure of Hereditary Cancer Risk Information to Relatives [J].
de Geus, Eveline ;
Aalfs, Cora M. ;
Menko, Fred H. ;
Sijmons, Rolf H. ;
Verdam, Mathilde G. E. ;
de Haes, Hanneke C. J. M. ;
Smets, Ellen M. A. .
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 2015, 22 (04) :551-560