EFFECT OF HYALURONAN ON THE ELASTASE-TYPE ACTIVITY OF HUMAN SKIN FIBROBLASTS

被引：13

作者：

BERNARD, E ^{[1
]}

HORNEBECK, W ^{[1
]}

ROBERT, L ^{[1
]}

机构：

[1] FAC MED CRETEIL,BIOL TISSU CONJONCT LAB,CNRS,ER 74,F-94010 CRETEIL,FRANCE

来源：

CELL BIOLOGY INTERNATIONAL | 1994年 / 18卷 / 10期

关键词：

FIBROBLASTS; HYALURONAN; ELASTASE-TYPE ACTIVITY;

D O I：

10.1006/cbir.1994.1017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The influence of hyaluronan (TIA) on the expression of human skin fibroblast elastase-type protease (HSFEp) (Homsy et al, 1988) was studied. At confluency of HSF cultures, hyaluronan increased the level of HSFEp in a time and dose-dependent fashion. Optimal effect was observed after 48 h of culture and at 2 mg/ml HA concentration; the stimulatory effect of HA could be suppressed by 1 mu M cycloheximide. The enhancement of enzyme biosynthesis by HA was dependent on cell proliferation but quasi invariant with HSF passage number (from 7-21).

引用

页码：967 / 971

页数：5

共 16 条

[1] SUPPRESSIVE EFFECTS OF HYALURONIC-ACID ON ELASTASE RELEASE FROM RAT PERITONEAL LEUKOCYTES [J].

AKATSUKA, M ;

YAMAMOTO, Y ;

TOBETTO, K ;

YASUI, T ;

ANDO, T .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1993, 45 (02) :110-114

[2]

ARCHILLAMARCOS M, 1994, CLIN PHYSIOL BIOCH, V10, P86

[3] CHARACTERIZATION AND PURIFICATION OF THE HYALURONAN-RECEPTOR ON LIVER ENDOTHELIAL-CELLS [J].

FORSBERG, N ;

GUSTAFSON, S .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1078 (01) :12-18

[4] EFFECT OF ELASTIN PEPTIDES ON HUMAN-MONOCYTES - CA-2+ MOBILIZATION, STIMULATION OF RESPIRATORY BURST AND ENZYME-SECRETION [J].

FULOP, T ;

JACOB, MP ;

VARGA, Z ;

FORIS, G ;

LEOVEY, A ;

ROBERT, L .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 141 (01) :92-98

[5]

GHUYSENITARD AF, 1992, CR HEBD ACAD SCI, V3, P473

[6] CHARACTERIZATION OF HUMAN-SKIN FIBROBLASTS ELASTASE ACTIVITY [J].

HOMSY, R ;

PELLETIERLEBON, P ;

TIXIER, JM ;

GODEAU, G ;

ROBERT, L ;

HORNEBECK, W .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1988, 91 (05) :472-477

[7]

HOMSY R, 1989, ELASTIN ELASTASES, V2, P57

[8] INCREASED SECRETION OF LATENT ELASTASE ACTIVITY FOLLOWING CONTACT BETWEEN HUMAN SKIN FIBROBLASTS AND ELASTIN DERIVED PEPTIDES [J].

LANDEAU, JM ;

PELLAT, B ;

HORNEBECK, W .

CELL BIOLOGY INTERNATIONAL, 1994, 18 (02) :111-117

[9] EFFECT OF TESTICULAR HYALURONIDASE ON HYALURONATE SYNTHESIS BY HUMAN-SKIN FIBROBLASTS IN CULTURE [J].

LARNIER, C ;

KERNEUR, C ;

ROBERT, L ;

MOCZAR, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1014 (02) :145-152

[10] CATABOLISM OF HYALURONAN IN RABBIT SKIN TAKES PLACE LOCALLY, IN LYMPH-NODES AND LIVER [J].

LAURENT, UBG ;

DAHL, LB ;

REED, RK .

EXPERIMENTAL PHYSIOLOGY, 1991, 76 (05) :695-703

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