THE MATERNAL GENES APX-1 AND GLP-1 AND ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE EARLY C-ELEGANS EMBRYO

被引：186
作者：
MELLO, CC [1 ]
DRAPER, BW [1 ]
PRIESS, JR [1 ]
机构：
[1] UNIV WASHINGTON, DEPT ZOOL, SEATTLE, WA 98195 USA
来源：
CELL | 1994年 / 77卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0092-8674(94)90238-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sister blastomeres ABp and ABa are equipotent at the beginning of the 4-cell stage in C. elegans embryos, but soon become committed to different fates. We show that the glp-1 gene, a homolog of the Notch gene of Drosophila, functions in two distinct cell-cell interactions that specify the ABp and ABa fates. These interactions both require maternal expression of glp-1. We show that a second maternal gene, apx-1, functions with glp-1 only in the specification of the ABp fate and that apx-1 can encode a protein homologous to the Delta protein of Drosophila. Our results suggest how interactions mediated by glp-1 and apx-1 contribute to the establishment of the dorsal-ventral axis in the early C. elegans embryo.
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页码：95 / 106
页数：12
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