NMDA-EVOKED ADENOSINE RELEASE FROM RAT CORTEX DOES NOT REQUIRE THE INTERMEDIATE FORMATION OF NITRIC-OXIDE

被引：20

作者：

CRAIG, CG ^{[1
]}

WHITE, TD ^{[1
]}

机构：

[1] DALHOUSIE UNIV,DEPT PHARMACOL,HALIFAX B3H 4H7,NS,CANADA

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 02期

关键词：

ADENOSINE; PURINE; NITRIC OXIDE; CORTEX; NMDA; RELEASE;

D O I：

10.1016/0304-3940(93)90255-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Excitatory amino acids (EAAs) such as glutamate release the inhibitory neuromodulator adenosine from superfused rat cortical slices through the activation of both NMDA and non-NMDA EAA receptors. This study investigated the possibility that NMDA-evoked adenosine release may involve the intermediate formation of nitric oxide (NO). However, sodium nitroprusside did not evoke the release of adenosine, L-arginine did not augment and L-N(upsilon)-nitroarginine did not diminish NMDA-evoked adenosine release. It appears. therefore, that NMDA-evoked NO formation does not play a role in NMDA-evoked adenosine release in the cortex.

引用

页码：167 / 169

页数：3

共 20 条

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